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Article

Promises and pitfalls of a Pannexin1 transgenic mouse line

1 Jan 2013

Abstract excerpt

Gene targeting strategies have become a powerful technology for elucidating mammalian gene function. The recently generated knockout (KO)-first strategy produces a KO at the RNA processing level and also allows for the generation of conditional KO alleles by combining FLP/FRT and Cre/loxP systems, thereby providing high flexibility in gene manipulation. However, this multipurpose KO-first cassette might produce...

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PMID: 23675350
DOI: 10.3389/fphar.2013.00061

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