Article
Aging Changes in Bladder Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Are Associated With Increasing Heterogeneity of Adrenergic/Mucosal Influence on Detrusor Control in the Mouse.
The journals of gerontology. Series A, Biological sciences and medical sciences - 14 Jun 2021
Hardy Cara C, Al-Naggar Iman M, Kuo Chia-Ling, Kuchel George A, Smith Phillip P
Abstract excerpt
A geroscience-informed approach to the increasing prevalence of bladder control problems in older adults requires understanding the impact of aging on dynamic mechanisms that ensure resilience in response to stressors challenging asymptomatic voluntary control over urine storage and voiding. Bladder control is predicated on sensory neural information about bladder volume. Modulation of volume-induced bladder wall...
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