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At the cross-point of connexins, calcium, and ATP: blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries.

Cardiovascular research - 1 Feb 2017

Bol Mélissa, Wang Nan, De Bock Marijke, Wacquier Benjamin, Decrock Elke, Gadicherla Ashish, Decaluwé Kelly, Vanheel Bert, van Rijen Harold Victor Maria, Krysko Dmitri Vadim, Bultynck Geert, Dupont Geneviève, Van de Voorde Johan, Leybaert Luc

Abstract excerpt

AIMS: Connexins form gap-junctions (GJs) that directly connect cells, thereby coordinating vascular cell function and controlling vessel diameter and blood flow. GJs are composed of two hemichannels contributed by each of the connecting cells. Hemichannels also exist as non-junctional channels that, when open, lead to the entry/loss of ions and the escape of ATP. Here we investigated cross-talk between...

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PMID: 27677282
DOI: 10.1093/cvr/cvw215

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