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Article

Smooth muscle-specific dystrophin expression improves aberrant vasoregulation in mdx mice

15 Jun 2006

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a fatal X-linked muscle-wasting disease caused by mutations of the gene encoding the cytoskeletal protein dystrophin. Therapeutic options for DMD are limited because the pathogenetic mechanism by which dystrophin deficiency produces the clinical phenotype remains obscure. Recent reports of abnormal alpha-adrenergic vasoregulation in the exercising muscles of DMD patients and...

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PMID: 16777842
DOI: 10.1093/hmg/ddl151

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