Article

Longitudinal change in mitochondrial heteroplasmy exhibits positive selection for deleterious variants

2024-03-28

Abstract excerpt

A common feature of human aging is the acquisition of somatic mutations, and mitochondria are particularly prone to mutation due to their inefficient DNA repair and close proximity to reactive oxygen species, leading to a state of mitochondrial DNA heteroplasmy 1,2 . Cross-sectional studies have demonstrated that detection of heteroplasmy increases with participant age 3 , a phenomenon that has been attributed to...

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Literature Corpus work: f0e10b49-b340-516d-a902-d4d6c85137ce
DOI: 10.1101/2024.03.27.24304930

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