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Article

Neutral mitochondrial heteroplasmy and the influence of aging.

Human molecular genetics - 15 Apr 2011

Sondheimer Neal, Glatz Catherine E, Tirone Jack E, Deardorff Matthew A, Krieger Abba M, Hakonarson Hakon

Abstract excerpt

The development and maintenance of mitochondrial heteroplasmy has important consequences for both health and heredity. Previous studies using pathogenic mutations have shown considerable variability between maternally related individuals and studies of several D-loop polymorphisms have suggested a relationship between heteroplasmy and somatic aging. To broadly explore the variation of human heteroplasmy and to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21296868
DOI: 10.1093/hmg/ddr043
PMCID: PMC3063991

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