Article

Mitochondrial mutation, drift and selection during human development and ageing

2023-06-26

Abstract excerpt

<title>Abstract</title> <p>Progressive dysfunction of mitochondria, organelles responsible for energy provision to cells, is a major hallmark of ageing. How the dysfunction steadily accrues over a lifetime remains unclear, given the transient nature of free radical damage and the high turnover of mitochondria. Here, we leveraged whole-genome sequencing data from single-cell derived foetal and adult haematopoietic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8705bd88-3ed0-534b-8520-545b1f994a4a
DOI: 10.21203/rs.3.rs-3083262/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial mutation, drift and selection during human development and ageingDOI 10.21203/rs.3.rs-3083262/v1Read

Selection promotes age-dependent degeneration of the mitochondrial genomeSemantic proximity Read

Mechanism of age-related accumulation of mitochondrial DNA mutations in human bloodSemantic proximity Read

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.Semantic proximity Read

Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout ageing.Semantic proximity Read

Mitochondrial DNA mosaicism in normal human somatic cells.Semantic proximity Read

Mitochondrial DNA mosaicism in human normal somatic cellsSemantic proximity Read

Large-scale single-cell mapping of concealed mitochondrial ageingSemantic proximity Read

The road to rack and ruin: selecting deleterious mitochondrial DNA variants.Semantic proximity Read

Ageing and mammalian mitochondrial genetics.Semantic proximity Read

The rise and rise of mitochondrial DNA mutations.Semantic proximity Read

Mechanism of age-related accumulation of mtDNA mutations in human blood.Semantic proximity Read

Mitochondrial DNA mutations in human oocytes undergo frequency-dependent selection but do not increase with ageSemantic proximity Read