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Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood

2025-05-28

Abstract excerpt

<h4>ABSTRACT</h4> One of the strongest signatures of aging is an accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy. Here we investigate the mechanism underlying this phenomenon by calling mtDNA sequence, abundance, and heteroplasmic variation in human blood using whole genome sequences from ∼750,000 individuals. Our analyses reveal a simple, two-step mechanism: first, individual cells randomly accumul...

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Literature Corpus work
e553cd2c-a9a7-528f-9428-f1b9c8972b39
DOI
10.1101/2025.05.25.655566
Open publication

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Mechanism of age-related accumulation of mitochondrial DNA mutations in human bloodDOI 10.1101/2025.05.25.655566
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