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Article

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.

Nature reviews. Genetics - 1 Sept 2015

Stewart James B, Chinnery Patrick F

Abstract excerpt

Common genetic variants of mitochondrial DNA (mtDNA) increase the risk of developing several of the major health issues facing the western world, including neurodegenerative diseases. In this Review, we consider how these mtDNA variants arose and how they spread from their origin on one single molecule in a single cell to be present at high levels throughout a specific organ and, ultimately, to contribute to the...

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PMID: 26281784
DOI: 10.1038/nrg3966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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