Article

Selection promotes age-dependent degeneration of the mitochondrial genome

2024-09-28

Abstract excerpt

Somatic mutations in mitochondrial genomes (mtDNA) accumulate exponentially during aging. Using single cell sequencing, we characterize the spectrum of age-accumulated mtDNA mutations in mouse and human liver and identify directional forces that accelerate the accumulation of mutations beyond the rate predicted by a neutral model. “Driver” mutations that give genomes a replicative advantage rose to high cellular a...

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Literature Corpus work: 499f59e3-afee-533f-b085-7c76aca9ec3b
DOI: 10.1101/2024.09.27.615276

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