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Article

Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2015

Li Mingkun, Schröder Roland, Ni Shengyu, Madea Burkhard, Stoneking Mark

Abstract excerpt

Heteroplasmy in human mtDNA may play a role in cancer, other diseases, and aging, but patterns of heteroplasmy variation across different tissues have not been thoroughly investigated. Here, we analyzed complete mtDNA genome sequences at ∼3,500× average coverage from each of 12 tissues obtained a...

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Identifiers

PMID: 25675502
DOI: 10.1073/pnas.1419651112
PMCID: PMC4345623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-25675502-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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