Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2015

Li Mingkun, Schröder Roland, Ni Shengyu, Madea Burkhard, Stoneking Mark

Abstract excerpt

Heteroplasmy in human mtDNA may play a role in cancer, other diseases, and aging, but patterns of heteroplasmy variation across different tissues have not been thoroughly investigated. Here, we analyzed complete mtDNA genome sequences at ∼3,500× average coverage from each of 12 tissues obtained at autopsy from each of 152 individuals. We identified 4,577 heteroplasmies (with an alternative allele frequency of at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Infant

Share to Infant, Newborn

Share to Organ Specificity

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 25675502
DOI: 10.1073/pnas.1419651112
PMCID: PMC4345623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations.PMID 25675502Read ↗

Heteroplasmic Mitochondrial Genetic Variation in the Human HeartSemantic proximity Read ↗

Sharing of heteroplasmies between human liver lobes varies across the mtDNA genomeSemantic proximity Read ↗

Age-related and heteroplasmy-related variation in human mtDNA copy numberSemantic proximity Read ↗

Mitochondrial genetic variation across tissues of the human body.Semantic proximity Read ↗

Presence and Transmission of Mitochondrial Heteroplasmic Mutations in Human Populations of European and African AncestrySemantic proximity Read ↗

Extreme heterogeneity of human mitochondrial DNA from organelles to populations.Semantic proximity Read ↗

Nuclear genetic control of mtDNA copy number and heteroplasmy in humansSemantic proximity Read ↗

Selection promotes age-dependent degeneration of the mitochondrial genomeSemantic proximity Read ↗

Deep sequencing of the mitochondrial genome reveals common heteroplasmic sites in NADH dehydrogenase genes.Semantic proximity Read ↗

Cancer-specific SNPs originate from low-level heteroplasmic variants in human mitochondrial genomes of a matched cell line pair.Semantic proximity Read ↗

Recurrent tissue-specific mtDNA mutations are common in humans.Semantic proximity Read ↗

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.