Article
mtDNA mutations in human aging and longevity: controversies and new perspectives opened by high-throughput technologies.
Experimental gerontology - 1 Aug 2014
Sevini Federica, Giuliani Cristina, Vianello Dario, Giampieri Enrico, Santoro Aurelia, Biondi Fiammetta, Garagnani Paolo, Passarino Giuseppe, Luiselli Donata, Capri Miriam, Franceschi Claudio, Salvioli Stefano
Abstract excerpt
The last 30 years of research greatly contributed to shed light on the role of mitochondrial DNA (mtDNA) variability in aging, although contrasting results have been reported, mainly due to bias regarding the population size and stratification, and to the use of analysis methods (haplogroup classification) that resulted to be not sufficiently adequate to grasp the complexity of the phenomenon. A 5-years European...
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