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Article

Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality.

Scientific reports - 8 Aug 2018

Tranah Gregory J, Katzman Shana M, Lauterjung Kevin, Yaffe Kristine, Manini Todd M, Kritchevsky Stephen, Newman Anne B, Harris Tamara B, Cummings Steven R

Abstract excerpt

Mitochondria contain many copies of a circular DNA molecule (mtDNA), which has been observed as a mixture of normal and mutated states known as heteroplasmy. Elevated heteroplasmy at a single mtDNA site, m.3243A > G, leads to neurologic, sensory, movement, metabolic, and cardiopulmonary impairments. We measured leukocyte mtDNA m.3243A > G heteroplasmy in 789 elderly men and women from the bi-racial,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30089816
DOI: 10.1038/s41598-018-30255-6
PMCID: PMC6082898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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