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Article

Independent impacts of aging on mitochondrial DNA quantity and quality in humans.

BMC genomics - 21 Nov 2017

Zhang Ruoyu, Wang Yiqin, Ye Kaixiong, Picard Martin, Gu Zhenglong

Abstract excerpt

BACKGROUND: The accumulation of mitochondrial DNA (mtDNA) mutations, and the reduction of mtDNA copy number, both disrupt mitochondrial energetics, and may contribute to aging and age-associated phenotypes. However, there are few genetic and epidemiological studies on the spectra of blood mtDNA heteroplasmies, and the distribution of mtDNA copy numbers in different age groups and their impact on age-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29157198
DOI: 10.1186/s12864-017-4287-0
PMCID: PMC5697406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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