Article

In-Vitro Cell-Model Investigation of Alpha-Synuclein Aggregate Morphology Using Spectroscopic Imaging

2024-10-28

Abstract excerpt

Recently, it has been hypothesized that alpha-synuclein protein strain morphology may be as-sociated to clinical subtypes of alpha-synucleinopathies like Parkinson’s disease and multiple system atrophy. However, direct evidence is lacking due to a caveat of conformation-specific characterization of protein strain morphology. Here we present a new cell model based in-vitro method to explore various alpha-synuclein...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0dba871-93a5-5928-b064-44dfe0ab46d7
DOI: 10.20944/preprints202410.2093.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In-Vitro Cell-Model Investigation of Alpha-Synuclein Aggregate Morphology Using Spectroscopic ImagingDOI 10.20944/preprints202410.2093.v1Read

Structural conversion of α-synuclein at the mitochondria induces neuronal toxicitySemantic proximity Read

Distinct neurotoxic TDP-43 fibril polymorphs can be generated by heterotypic interactions with α-synucleinSemantic proximity Read

Binding adaptability of chemical ligands to polymorphic α-synuclein amyloid fibrils.Semantic proximity Read

Familial Mutations May Switch Conformational Preferences in α-Synuclein Fibrils.Semantic proximity Read

Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neuronsSemantic proximity Read

Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding AntibodiesSemantic proximity Read

Distinct alpha-synuclein strains derived from Parkinson’s disease patient tissues trigger differential inclusion pathology in a novel biosensor cell modelSemantic proximity Read

Conformational dynamics of Tau in the cell quantified by an intramolecular FRET biosensor in physiological and pathological contextSemantic proximity Read

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profilesSemantic proximity Read

Change in the Oligomeric State of α-Synuclein Variants in Living Cells.Semantic proximity Read

Wildtype and A30P mutant alpha-synuclein form different fibril structures.Semantic proximity Read

α-Synuclein Conformational Strains as Drivers of Phenotypic Heterogeneity in Neurodegenerative DiseasesSemantic proximity Read