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Change in the Oligomeric State of α-Synuclein Variants in Living Cells.

ACS chemical neuroscience - 20 Apr 2022

Fan Hsiu-Fang, Chen Wen-Ling, Chen Yan-Zhow, Huang Jian-Wei, Shen Yu-Xin

Abstract excerpt

The accumulation of β-sheet-rich α-synuclein (α-Syn) protein in human brain cells is a pathological hallmark of Parkinson's disease (PD). Moreover, it has been reported that familial PD mutations (A30P, E46K, H50Q, G51D, and A53T) accumulate at an accelerated rate both in vivo and in vitro. In addition, accumulations of various C-terminal α-Syn truncations, such as C-terminal-truncated N103 α-synuclein (N103),...

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PMID: 35394271
DOI: 10.1021/acschemneuro.1c00646

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