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Article

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

2023-10-06

Abstract excerpt

The alpha-synuclein ( α Syn) seeding amplification assay (SAA) that allows the generation of disease-specific in vitro seeded fibrils (SAA fibrils) is used as a research tool to study the connection between the structure of α Syn fibrils, cellular seeding/spreading, and the clinico-pathological manifestations of different synucleinopathies. However, structural differences between human brain-derived and SAA α S...

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Literature Corpus work
c8b09e3b-65a1-5896-9a61-b04880d84816
DOI
10.1101/2023.10.04.560803
Open publication

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Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profilesDOI 10.1101/2023.10.04.560803
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