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Article

Wildtype and A30P mutant alpha-synuclein form different fibril structures.

PloS one - 1 Jan 2013

Nielsen Søren Bang, Macchi Francesca, Raccosta Samuele, Langkilde Annette Eva, Giehm Lise, Kyrsting Anders, Svane Anna Sigrid Pii, Manno Mauro, Christiansen Gunna, Nielsen Niels Christian, Oddershede Lene, Vestergaard Bente, Otzen Daniel Erik

Abstract excerpt

Parkinson's Disease (PD) is a neurodegenerative movement disorder affecting millions of people worldwide. One of the key players in the development of the disease is the protein α-synuclein (aSN), which aggregates in the brain of PD patients. The aSN mutant A30P has been reported to cause early-onset familial PD and shows different aggregation behavior compared to wt aSN. Here we use a multidisciplinary approach...

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PMID: 23861789
DOI: 10.1371/journal.pone.0067713
PMCID: PMC3701545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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