Article

Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons

2020-02-12

Abstract excerpt

The conformational strain diversity characterizing α-synuclein (α-syn) amyloid fibrils is possibly at the origin of the different clinical presentations of synucleinopathies. Experimentally, various α-syn fibril polymorphs have been obtained from distinct fibrillization conditions by altering the medium constituents and were selected by amyloid monitoring using the probe Thioflavin T (ThT). We report here that bes...

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Literature Corpus work: 2eb3f240-4c42-5999-85cb-c4130f19b56c
DOI: 10.1101/2020.02.11.943670

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