Article

Asprosin–PTPRD endocrine resistance links brain dysfunction and systemic wasting in Alzheimer’s disease

2026-06-17

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) is characterized by cognitive decline and systemic frailty, but mechanisms linking brain dysfunction to organismal wasting remain unclear. We identify PTPRD, a human-genetically supported regulator of tau pathology, as a high-affinity receptor for amyloid-β (Aβ). Aβ competitively binds the PTPRD extracellular domain, opposing the endogenous ligand asprosin and p...

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Literature Corpus work: f08c89f1-b456-5232-8e7c-55b4cc2820fd
DOI: 10.21203/rs.3.rs-9972826/v1

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