Article

Global metabolic reprogramming and sex-specific impact of caloric restriction in a mouse model of Alzheimer’s disease

2025-05-28

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease (AD), disproportionally affecting women, is generally regarded as a disease of the brain. Yet, cumulative evidence increasingly supports a more systemic, full-body view on this incurable disorder, with the liver and kidneys playing an important role in amyloid clearance. The latter is likely potentiated by caloric restriction (CR), but its impact on the metabolism of key am...

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Literature Corpus work: 12b90df7-6a25-5d1d-bce1-544a99c36b8e
DOI: 10.1101/2025.05.24.655912

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