Article

Alzheimer-related pathogenesis is dependent on neuronal receptor PTPσ

2016-10-07

Abstract excerpt

Due to limited understanding of disease mechanisms and the lack of molecular targets, translational research for Alzheimer disease has not been fruitful hitherto. Here we report findings that indicate neuronal receptor phosphatase PTPσ as a potential therapeutic target for this dementia. In two TgAPP mouse models, a spectrum of Alzheimer-related pathologies, including aged-induced progression of β-amyloidosis, Tau...

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Literature Corpus work: f8c27309-2f6c-5a5d-90a2-e33464bdcb09
DOI: 10.1101/079806

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