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Article

Region-specific vulnerability in neurodegeneration: lessons from normal ageing

24 Feb 2021

Abstract excerpt

A number of age-associated neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), possess a shared characteristic of region-specific neurodegeneration. However, the mechanisms which determine why particular regions within the nervous system are selectively vulnerable to neurodegeneration, whilst others remain relatively unaffected...

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PMID: 33639280
DOI: 10.1016/j.arr.2021.101311

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