Article

ADAM10- and presenilin 1/g-secretase-dependent cleavage of PTPRT mitigates Neurodegeneration of Alzheimer’s disease

2021-03-30

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>PTPRT (receptor-type tyrosine-protein phosphatase T), as a brain-specific type 1 transmembrane protein, plays an important function in neurodevelopment and synapse formation. However, whether PTPRT-dependent signaling is involved in Alzheimer’s disease (AD) remains elusive. <bold>Methods</bold>We have begun to address these questions by investigation of the relati...

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Literature Corpus work: 3ebec6d9-c801-58e9-8ab3-7ecf359216da
DOI: 10.21203/rs.3.rs-327896/v1

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