Article

Heterozygous Lepr Mutation Accelerates Alzheimer-like Neurodegeneration in db/+ Mice via CDK5 Hyperactivation

2025-09-02

Abstract excerpt

<h4>ABSTRACT</h4> Leptin signaling has neuroprotective effects and is increasingly linked to Alzheimer’s disease (AD). Beyond metabolism, leptin modulates β-amyloid metabolism, tau phosphorylation, and synaptic plasticity. While homozygous Lepr mutations are well studied, the impact of heterozygous mutations on neurodegeneration is unclear. To assess partial Lepr loss, one-year-old db/+ mice were evaluated for me...

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Literature Corpus work: 385b711b-80f6-5714-9bf5-71446a45771b
DOI: 10.1101/2025.08.28.672812

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Heterozygous Lepr Mutation Accelerates Alzheimer-like Neurodegeneration in db/+ Mice via CDK5 HyperactivationDOI 10.1101/2025.08.28.672812Read

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