Article

AETA peptide drives Alzheimer’s disease signature of synapse dysfunction

2025-12-01

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD), the leading cause of dementia, is characterized by early synaptic dysfunction that precedes overt cognitive decline. While amyloid-β and Tau remain central to AD pathogenesis, molecular triggers of synapse weakening remain unclear. Here, we investigated AETA, a novel brain-secreted peptide derived from amyloid precursor protein (APP), as a potential mediator of...

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Literature Corpus work: f463b7d5-9d0b-5aed-aff8-3d48141fc51b
DOI: 10.21203/rs.3.rs-8192959/v1

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