Article

Thiamine pyrophosphokinase-1 deficiency in neurons drives Alzheimer’s multiple pathophysiological alterations

2024-09-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The mechanism driving multiple pathophysiological alterations in Alzheimer’s disease (AD) remains unclear. Thiamine deficiency, a well-known feature of AD, may contribute to these alterations. <h4>Methods</h4> The expressions of four known genes associated with thiamine metabolism were studied in brain samples from patients with AD and other neurodegenerative disorders. The re...

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Literature Corpus work: 9de81a71-1a76-53ae-8650-ee05d319bfd8
DOI: 10.1101/2024.09.20.24314010

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