Article

Inter-kingdom signaling by the <i>Legionella</i> autoinducer LAI-1 involves the antimicrobial guanylate binding protein GBP

2024-09-28

Abstract excerpt

The causative agent of Legionnaires’ disease, Legionella pneumophila , is an amoebae-resistant environmental bacterium, which replicates intracellularly in a distinct compartment, the “ Legionella -containing vacuole” (LCV). L. pneumophila employs the α-hydroxyketone compound LAI-1 ( Legionella autoinducer-1) for intra-species and inter-kingdom signaling. LAI-1 promotes intracellular replication and inhibits t...

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Literature Corpus work: f03be833-bcbe-5323-89c2-dbe1ef56e71f
DOI: 10.1101/2024.09.27.615321

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