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Article

Secrets of a Successful Pathogen: Legionella Resistance to Progression Along the Autophagic Pathway

1 Jan 2011

Abstract excerpt

To proliferate within phagocytes, Legionella pneumophila relies on Type IV secretion to modulate host cellular pathways. Autophagy is an evolutionarily conserved degradative pathway that captures and transfers a variety of microbes to lysosomes. Biogenesis of L. pneumophila-containing vacuoles and autophagosomes share several features, including endoplasmic reticulum (ER)-derived membranes, contributions by the...

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PMID: 21743811
DOI: 10.3389/fmicb.2011.00138

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