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Autophagy Evasion and Endoplasmic Reticulum Subversion: The Yin and Yang of<i>Legionella</i>Intracellular Infection

8 Sept 2016

Abstract excerpt

The gram-negative bacterial pathogen Legionella pneumophila creates a novel organelle inside of eukaryotic host cells that supports intracellular replication. The L. pneumophila-containing vacuole evades fusion with lysosomes and interacts intimately with the host endoplasmic reticulum (ER). Although the natural hosts for L. pneumophila are free-living protozoa that reside in freshwater environments, the...

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PMID: 27607556
DOI: 10.1146/annurev-micro-102215-095557

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