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<i>Toxoplasma</i> -proximal and distal control by GBPs in human macrophages

1 Dec 2021

Abstract excerpt

Human guanylate binding proteins (GBPs) are key players of interferon-gamma (IFNγ)-induced cell intrinsic defense mechanisms targeting intracellular pathogens. In this study, we combine the well-established Toxoplasmagondii infection model with three in vitro macrophage culture systems to delineate the contribution of individual GBP family members to control this apicomplexan parasite. Use of high-throughput...

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PMID: 34931666
DOI: 10.1093/femspd/ftab058

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