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Effector-mediated subversion of proteasome activator (PA)28αβ enhances host defense against <i>Legionella pneumophila</i> under inflammatory and oxidative stress conditions

2021-12-27

Abstract excerpt

Legionella pneumophila is a natural pathogen of amoebae that causes Legionnaires’ Disease in immunocompromised individuals via replication within macrophages. L. pneumophila virulence and intracellular replication hinges on hundreds of Dot/Icm-translocated effector proteins, which are essential for biogenesis of the replication permissive Legionella -containing vacuole (LCV). However, effector activity can also...

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Identifiers and source

Literature Corpus work
d292561e-d90e-582d-b21f-0a9d90fa649f
DOI
10.1101/2021.12.27.473672
Open publication

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