Article

KKL-35 exhibits potent antibiotic activity against <i>Legionella</i> species independently of trans-translation inhibition

2017-05-15

Abstract excerpt

Trans-translation is a ribosome rescue system that is ubiquitous in bacteria. Small molecules defining a new family of oxadiazole compounds that inhibit trans-translation have been found to have broad-spectrum antibiotic activity. We sought to determine the activity of KKL-35, a potent member of the oxadiazole family, against the human pathogen Legionella pneumophila and other related species that can also cause...

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Literature Corpus work: ed248295-908f-581e-8ef3-c3ed7d526297
DOI: 10.1101/135798

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