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Article

De-AMPylation of the Small GTPase Rab1 by the Pathogen <i>Legionella pneumophila</i>

17 Jun 2011

Abstract excerpt

The bacterial pathogen Legionella pneumophila exploits host cell vesicle transport by transiently manipulating the activity of the small guanosine triphosphatase (GTPase) Rab1. The effector protein SidM recruits Rab1 to the Legionella-containing vacuole (LCV), where it activates Rab1 and then AMPylates it by covalently adding adenosine monophosphate (AMP). L. pneumophila GTPase-activating protein LepB inactivates...

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PMID: 21680813
DOI: 10.1126/science.1207193

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Related research

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Click a neighbor to travelStep 1 · 12 closest

De-AMPylation of the Small GTPase Rab1 by the Pathogen <i>Legionella pneumophila</i>PMID 21680813Read ↗

Legionella pneumophila SidD is a deAMPylase that modifies Rab1.Semantic proximity Read ↗

Legionella pneumophila LidA Affects Nucleotide Binding and Activity of the Host GTPase Rab1Semantic proximity Read ↗

Targeting of the Small GTPase Rab6A′ by the Legionella pneumophila Effector LidASemantic proximity Read ↗

Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA.Semantic proximity Read ↗

Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidDSemantic proximity Read ↗

Inter-kingdom signaling by the <i>Legionella</i> autoinducer LAI-1 involves the antimicrobial guanylate binding protein GBPSemantic proximity Read ↗

Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila.Semantic proximity Read ↗

The <i>Legionella pneumophila</i> type IVb secretion system effector BinA subverts amino acid transport to sensitize TORC1 signaling in macrophagesSemantic proximity Read ↗

Taking control: Hijacking of Rab GTPases by intracellular bacterial pathogensSemantic proximity Read ↗

Protein LidA from Legionella is a Rab GTPase supereffectorSemantic proximity Read ↗

The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor.Semantic proximity Read ↗

Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila.Semantic proximity Read ↗

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