Article

The <i>MS4A</i> gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk

2018-06-20

Abstract excerpt

Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) levels in the cerebrospinal fluid (CSF) have been associated with Alzheimer disease (AD) status. TREM2 plays a critical role in microglial activation, survival, and phagocytosis; however, the pathophysiological role of sTREM2 in AD is not well understood. Understanding the role of sTREM2 in AD may help reveal biological mechanisms underlying AD and...

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Literature Corpus work: 5a3b8273-55f6-517d-a382-3c5ef3766e4e
DOI: 10.1101/352179

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