Article

Large-scale population analysis of SARS-CoV-2 whole genome sequences reveals host-mediated viral evolution with emergence of mutations in the viral Spike protein associated with elevated mortality rates

2020-10-27

Abstract excerpt

<h4>Background</h4> We aimed to further characterize and analyze in depth intra-host variation and founder variants of SARS-CoV-2 worldwide up until August 2020, by examining in excess of 94,000 SARS-CoV-2 viral sequences in order to understand SARS-CoV-2 variant evolution, how these variants arose and identify any increased mortality associated with these variants. <h4>Methods and Findings</h4> We combined worldw...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 257ce331-7708-510f-b86a-b08eb60e1ac9
DOI: 10.1101/2020.10.23.20218511

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Large-scale population analysis of SARS-CoV-2 whole genome sequences reveals host-mediated viral evolution with emergence of mutations in the viral Spike protein associated with elevated mortality ratesDOI 10.1101/2020.10.23.20218511Read

SARS-CoV-2 Variants and Their Relevant Mutational Profiles: Update Summer 2021.Semantic proximity Read

Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolatesSemantic proximity Read

Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates.Semantic proximity Read

Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis.Semantic proximity Read

Perspectives: SARS-CoV-2 Spike Convergent Evolution as a Guide to Explore Adaptive Advantage.Semantic proximity Read

Intra-host evolution provides for continuous emergence of SARS-CoV-2 variantsSemantic proximity Read

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2Semantic proximity Read

Epidemiology and Characteristics of SARS-CoV-2 Variants of Concern: The Impacts of the Spike MutationsSemantic proximity Read

The landscape of SARS-CoV-2 genomic mutationsSemantic proximity Read

Preliminary report on SARS-CoV-2 Spike mutation T478KSemantic proximity Read

Emerging mutations in spike and other structural proteins of SARS-CoV-2Semantic proximity Read

Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas.Semantic proximity Read