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Article

High-throughput screening of mutations affecting SARS-CoV-2 spike functions.

Trends in immunology - 1 May 2023

Xia Shuai, Liu Zezhong, Jiang Shibo

Abstract excerpt

The spike (S) protein of SARS-CoV-2, which is undergoing rapid evolution, plays crucial roles in viral immune escape, infectivity, and transmissibility. To gain clinical insight, Dadonaite et al. developed a novel deep mutational scanning (DMS) platform for mapping the effects of S protein mutations on immune evasion and viral infectivity.

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Identifiers

PMID: 37031063
DOI: 10.1016/j.it.2023.03.010
PMCID: PMC10050277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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