Article

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases

2025-04-30

Abstract excerpt

<h4>Summary</h4> Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is unknown how CASP1 terminates its activity in vivo . Here, we use a knock-in mouse model in which the CASP1 CARD domain linker (CDL) is mutated to prevent self-cleavage ( Casp1.CDL mice) to show tha...

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Literature Corpus work: efd33223-b789-5dab-9c47-2759ea84c7e1
DOI: 10.1101/2025.04.28.651119

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