Article

IL-1β turnover by TRIP12 and AREL1 ubiquitin ligases and UBE2L3 limits inflammation

2022-09-14

Abstract excerpt

<h4>ABSTRACT</h4> The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites inflammatory pathology. Bioactive IL-1β is released following proteolytic maturation of the pro-IL-1β precursor by caspase-1 inflammasomes. UBE2L3/UBCH7, a conserved ubiquitin conjugating enzyme, promotes pro-IL-1β ubiquitylation and proteasomal disposal. However, UBE2L3 actions in vivo and ubiquit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3d093884-02d0-5d75-91ca-1f8a60043e97
DOI: 10.1101/2022.09.14.507790

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IL-1β turnover by TRIP12 and AREL1 ubiquitin ligases and UBE2L3 limits inflammationDOI 10.1101/2022.09.14.507790Read

Linear ubiquitination at a glanceSemantic proximity Read

An Update on Autoinflammatory Diseases: Relopathies.Semantic proximity Read

Current landscape of the immunoproteasome: implications for disease and therapySemantic proximity Read

Roles of ubiquitin-specific proteases in inflammatory diseasesSemantic proximity Read

Human LUBAC deficiency leads to autoinflammation and immunodeficiency by dysregulation in TNF-mediated cell deathSemantic proximity Read

The Ubiquitin System and A20: Implications in Health and DiseaseSemantic proximity Read

Regulation of inflammasome activation.Semantic proximity Read

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.Semantic proximity Read

Inflammasome Complexes: Emerging Mechanisms and Effector FunctionsSemantic proximity Read

Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.Semantic proximity Read

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.Semantic proximity Read

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and AutoimmunitySemantic proximity Read