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Article

Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death.

The EMBO journal - 21 Dec 2005

Brenner Dirk, Golks Alexander, Kiefer Friedemann, Krammer Peter H, Arnold Rüdiger

Abstract excerpt

Restimulation of the T-cell receptor (TCR) in activated T cells induces CD95 (Fas/Apo-1)-mediated activation-induced cell death (AICD). The TCR-proximal mechanisms leading to AICD are elusive. Here we characterize hematopoietic progenitor kinase 1 (HPK1) as a differentially regulated TCR-proximal signaling protein involved in AICD of primary T cells. We show that HPK1 is a functional component of the endogenous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16341093
DOI: 10.1038/sj.emboj.7600894
PMCID: PMC1356335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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