Article

Human caspase-1 autoproteolysis is required for ASC-dependent and -independent inflammasome activation

2019-06-24

Abstract excerpt

Pathogen-related signals induce a number of cytosolic pattern-recognition receptors (PRRs) to form canonical inflammasomes, which activate pro-caspase-1 and trigger pyroptotic cell death. All well-studied PRRs oligomerize with the pro-caspase-1-adapter protein ASC to generate a single large structure in the cytosol, which induces the autoproteolysis and activation of the pro-caspase-1 zymogen. However, several PRR...

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Literature Corpus work: f15022ca-62bc-57ed-aa25-47374232f45e
DOI: 10.1101/681304

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