Article

The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases

2023-02-16

Abstract excerpt

The mammalian innate immune system uses germline-encoded cytosolic pattern-recognition receptors (PRRs) to detect intracellular danger signals. At least six of these PRRs are known to form multiprotein complexes called inflammasomes which activate cysteine proteases known as caspases. Canonical inflammasomes recruit and activate caspase-1 (CASP1), which in turn cleaves and activates inflammatory cytokines such as...

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Literature Corpus work: 3d72599f-0031-50ec-8d19-dcc20ed8532e
DOI: 10.1101/2023.02.16.528859

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