Article

Caspase-1 regulates TBK1 and PPARα to suppress steatosis-associated hepatocarcinogenesis

2026-06-05

Abstract excerpt

<title>Abstract</title> <p> Metabolic dysfunction-associated steatohepatitis (MASH) is becoming a major driver of hepatocellular carcinoma (HCC). Caspase-1 (CASP1), a central component of the inflammasome complex, has been implicated in liver disease, but its specific role in MASH-associated HCC (MASH-HCC) remains unclear. Here, we investigated the functional role of CASP1 in MASH HCC using <italic>Casp1</itali...

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Literature Corpus work: f019c71c-ae7a-5c1e-a607-09ee1d960aaf
DOI: 10.21203/rs.3.rs-8435497/v1

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