Article
Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo.
Cell reports - 25 Feb 2020
Reinke Sören, Linge Mary, Diebner Hans H, Luksch Hella, Glage Silke, Gocht Anne, Robertson Avril A B, Cooper Matthew A, Hofmann Sigrun R, Naumann Ronald, Sarov Mihail, Behrendt Rayk, Roers Axel, Pessler Frank, Roesler Joachim, Rösen-Wolff Angela, Winkler Stefan
Abstract excerpt
Pro-inflammatory caspase-1 is a key player in innate immunity. Caspase-1 processes interleukin (IL)-1β and IL-18 to their mature forms and triggers pyroptosis. These caspase-1 functions are linked to its enzymatic activity. However, loss-of-function missense mutations in CASP1 do not prevent autoinflammation in patients, despite decreased IL-1β production. In vitro data suggest that enzymatically inactive...
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