Article

Glucose Metabolism Controls Oxidative Burst and Lipid Mediator Production in Neutrophils upon Microbial Challenge

2025-09-02

Abstract excerpt

<h4>SUMMARY</h4> Neutrophils are frontline responders against bacterial and fungal pathogens, requiring rapid energy and biosynthetic precursors to mount effective antimicrobial responses. To meet these demands, they primarily rely on aerobic glycolysis, making glucose uptake essential. Murine and human neutrophils express the glucose transporters GLUT1 and GLUT3; however, their specific roles in neutrophil immun...

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Literature Corpus work: ebf54fa9-4ed3-5806-a4d3-612747d643dd
DOI: 10.1101/2025.08.31.672068

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