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Article

CO2 Acts as a Signalling Molecule in Populations of the Fungal Pathogen Candida albicans

18 Nov 2010

Abstract excerpt

When colonising host-niches or non-animated medical devices, individual cells of the fungal pathogen Candida albicans expand into significant biomasses. Here we show that within such biomasses, fungal metabolically generated CO(2) acts as a communication molecule promoting the switch from yeast to filamentous growth essential for C. albicans pathology. We find that CO(2)-mediated intra-colony signalling involves...

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PMID: 21124988
DOI: 10.1371/journal.ppat.1001193

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