Article
Niche-specific regulation of central metabolic pathways in a fungal pathogen.
Cellular microbiology - 1 Jun 2006
Barelle Caroline J, Priest Claire L, Maccallum Donna M, Gow Neil A R, Odds Frank C, Brown Alistair J P
Abstract excerpt
To establish an infection, the pathogen Candida albicans must assimilate carbon and grow in its mammalian host. This fungus assimilates six-carbon compounds via the glycolytic pathway, and two-carbon compounds via the glyoxylate cycle and gluconeogenesis. We address a paradox regarding the roles of these central metabolic pathways in C. albicans pathogenesis: the glyoxylate cycle is apparently required for...
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