Article

Hyperglycemia promotes maladaptive Dectin-1 signaling and impairs skin antifungal host defense

2026-02-14

Abstract excerpt

People with chronic hyperglycemia are more susceptible to fungal skin infections, but the mechanisms underlying their worse clinical outcomes remain unclear. Using both in vivo and in vitro models, we explored how hyperglycemia influences skin antifungal defenses and how GLP1 agonists might restore host defense in diabetic conditions. Hyperglycemic mice showed increased susceptibility to Candida albicans skin i...

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Literature Corpus work: 595a95d8-8ef9-5099-bf53-6efc400636de
DOI: 10.64898/2026.02.11.705431

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