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<i>Aspergillus</i> -mediated allergic airway inflammation is triggered by dendritic cell recognition of a defined spore morphotype, a process that can be targeted via antifungal therapeutics

2024-01-11

Abstract excerpt

<h4>Background</h4> Exposure to fungi, especially Aspergillus fumigatus (A.f.) , can elicit potent allergic inflammation that triggers and worsens asthmatic disease. Dendritic cells (DCs), initiate allergic inflammatory responses to allergic stimuli. However, it is unclear if A.f. spores during isotropic growth (early spore swelling) can activate DCs to initiate allergic responses or if germination is required....

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Literature Corpus work
2ef33841-7dac-5b9d-ac47-1d785f499d01
DOI
10.1101/2024.01.11.575032
Open publication

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