Article

NCOR1 and OCT4 Facilitate Early Reprogramming by Co-Suppressing Fibroblast Gene Expression

2019-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Reprogramming somatic cells to induced pluripotent stem cells (iPSC) succeeds only in a small fraction of cells within the population. Reprogramming occurs in distinctive stages, each facing its own bottlenecks. It initiates with overexpression of transcription factors OCT4, SOX2, KLF4 and c-MYC (OSKM) in somatic cells such as mouse embryonic fibroblasts (MEFs). OSKM bind chromatin, silencing th...

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Literature Corpus work: cfd4acc3-6356-560f-b982-0aa136b2251a
DOI: 10.1101/747006

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